This panel convenes senior leaders from across the U.S. Air Force, U.S. Space Force, and the space industry to provide a comprehensive look at the pivotal role of Modeling and Simulation (M&S) in modernizing national defense. The discussion offers an opportunity to hear directly from the key decision-makers responsible for the entire capability lifecycle, from foundational research to operational command and control. Ultimately, this session is essential for anyone seeking to understand the digital transformation and strategic imperatives that are defining the future of multi-domain operations and M&S enabling capabilities.